Representatives of the remaining 16 teams in the Champions League will convene in Nyon for Monday's draw for the knockout stages.
Some of the continent's heavyweights had little difficulty booking their place, with Porto, Bayern Munich and Barcelona topping their respective groups unbeaten.
Juventus and holders Real Madrid also progressed as group winners, despite suffering shock defeats last week to Young Boys and CSKA Moscow, respectively.
Those who emerged as leaders in the round-robin phase will – theoretically at least – expect slightly kinder draws.
However, there are certainly a few jokers in the pack, with Atletico Madrid, Tottenham, Liverpool and Manchester United all going through as runners-up.
For most, the knockout phase is when the Champions League really starts to build the intrigue, but there are rules in place preventing clubs from facing other sides from the same nation or group in the last 16.
So, who could each team end up playing? We take a look at the draw scenarios.
UEFA Champions League last 16!
— UEFA Champions League (@ChampionsLeague) December 12, 2018
CONFIRMED
Best team left in the #UCL ? pic.twitter.com/7ecHZBlyNL
GROUP A
Borussia Dortmund : Ajax, Liverpool, Lyon, Manchester United, Roma, Tottenham
Atletico Madrid : Bayern, Juventus, Manchester City, Paris Saint-Germain, Porto
GROUP B
Barcelona : Liverpool, Schalke, Ajax, Lyon, Roma, Manchester United
Tottenham : Dortmund, PSG, Porto, Bayern, Real Madrid, Juventus
Confirmation of the possible rivals in the @ChampionsLeague Round of 16
— FC Barcelona (@FCBarcelona) December 12, 2018
Schalke 04
Liverpool and Manchester United
Roma
Ajax
Lyon
Who do you want in the next round?
Vote in our survey! https://t.co/yN0tSy8Cc6
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GROUP C
PSG : Atletico, Tottenham, Schalke, Ajax, Roma, Manchester United
Liverpool : Dortmund, Barcelona, Porto, Bayern, Real Madrid, Juventus
GROUP D
Porto : Atletico, Spurs, Liverpool, Ajax, Lyon, Roma, Manchester United
Schalke : Barcelona, PSG, Manchester City, Real Madrid, Juventus
The last 16 is set - who do you want to face, Schalke fans?
— FC Schalke 04 (@s04_en) December 12, 2018
@realmadriden
@FCBarcelona
@PSG_English
@ManCity
@juventusfcen
( @ChampionsLeague ) #s04 #UCL pic.twitter.com/L0sEW34icu
GROUP E
Bayern : Atletico, Spurs, Liverpool, Lyon, Roma, Manchester United
Ajax : Dortmund, Barcelona, PSG, Porto, Manchester City, Real Madrid, Juventus
GROUP F
Manchester City : Atletico, Schalke, Ajax, Roma
Lyon : Dortmund, Barcelona, Porto, Bayern, Real Madrid, Juventus
It’s going to be one of these four!
— Manchester City (@ManCity) December 12, 2018
Who do you want in the #UCL last 16? #mancity
GROUP G
Real Madrid : Spurs, Liverpool, Schalke, Ajax, Lyon, Manchester United
Roma : Dortmund, Barcelona, PSG, Porto, Bayern, Manchester City
GROUP H
Juventus : Atletico, Spurs, Liverpool, Schalke, Ajax, Lyon
Manchester United : Dortmund, Barcelona, PSG, Porto, Bayern, Real Madrid
When will the Champions League last-16 matches be played?
One half of the draw will play the first leg matches on 12 or 13 February, with the other four games contested a week later.
The return matches take place three weeks later, with the round completed on March 13.