Raheem Sterling will lead the line for Manchester City in the absence of Sergio Aguero against Chelsea, who start with Eden Hazard playing as a false nine.
Pep Guardiola opted for a pacey attacking trio of Leroy Sane, Riyad Mahrez and Sterling, who celebrated his 24th birthday on Saturday, while Gabriel Jesus had to settle for a place among the substitutes.
Maurizio Sarri dropped Alvaro Morata from the side that lost 2-1 to Wolves in midweek and opted for Hazard alongside Willian and Pedro in attack.
Chelsea go into the game desperate for three points after a disappointing result at Molineux that came in the away game after their 3-1 reverse against Tottenham.
City, meanwhile need a victory to reclaim top spot in the Premier League from Liverpool.