Kershaw allowed two runs and five hits in his three innings on the mound Saturday against New York.
The Cubs have scored a combined seven runs in three straight losses to the Reds.
Beltre, a four-time All-Star, has batted .305 with three home runs and 24 RBIs this season.
Edwin Jackson will start for the Athletics against the White Sox Sunday.
Santana blasted 30 home runs for Milwaukee last season, but he has struggled in 2018.
Greg Bird has struggled mightily this season, but Yankees manager Aaron Boone is confident in his first baseman.
Corey Kluber led the Indians past the Tigers with yet another dominant performance.
"Triple-A is not an answer," Conforto said. "I've been through that. I have done all I can do down there. I play at this level. That's it."
With his 343rd victory, Colon, 45, is two wins from tying Nicaragua-born Dennis Martinez for most by a pitcher from Latin America.
"I wanted to let everybody know Clay is alright. He's got a little boo-boo on his nose, but he'll be all right," Davante Adams said.