Rex Ryan has been fired by Buffalo Bills ending a disappointing two-year stint that failed to bring an end to the franchise's 17-season playoff drought.
The Bills announced the decision on Tuesday, with Ryan's brother Rob - the Bills' assistant coach - also dismissed.
Offensive coordinator Anthony Lynn will serve as interim coach for Sunday's season finale at the New York Jets and he could be in the mix for the head-coaching job in 2017.
Ryan, 54, served as Buffalo's ninth coach since the team last made the playoffs in 1998.
Bills owner Terry Pegula told the team's official website: "I spoke with Rex and we mutually agreed that the time to part ways is now.
"These decisions are never easy. I want to take this opportunity to thank Rex for all his efforts and wish him all the best moving forward."
His Day 1 proclamations that Buffalo would regularly lead the NFL in defense, his specialty, twice rang hollow.
The Bills' unit regressed significantly in Ryan's first season and remains a middling disaster in 2016, exposed in the most appropriate of ways in Week 14 when Pittsburgh Steelers' Le'Veon Bell bullied his way to 236 rushing yards, the most ever against a Buffalo defense, and three touchdowns.
In eight seasons as an NFL head coach, Ryan's Jets and Bills teams have a combined 61-66 record. Only twice have they reached the playoffs, in 2009 and 2010, Ryan's first two seasons in New York.
This season, the Bills (7-8) have one win over an opponent with a winning record - the Tom Brady-less New England Patriots in Week 4.
A myriad of reasons led to Ryan's undoing, but chief among them was his inability to see eye-to-eye with general manager Doug Whaley and other Bills decision makers, according to various reports.
Buffalo almost certainly will decline the option to pay struggling starting quarterback Tyrod Taylor $27.5 million next year, making him a free agent; Ryan was adamant on keeping him to lead the offense.