Guangzhou Evergrande hit Eastern for six in the AFC Champions League, thanks to a big contribution from Paulinho.
Al Ain took a big step toward the knockout stages in Group C, while Al Hilal became the first team to book their ticket for the next round.
Thai side Muangthong United continued their season of history-making with a win over Ulsan that put them top of Champions League Group E.
Shanghai SIPG fell to a first AFC Champions League defeat of the season to Urawa Red Diamonds as Oscar missed two second-half penalties.
Lekhwiya and Al-Hilal were the winners in Monday's AFC Champions League group-stage action.
Guangzhou Evergrande had to settle for a draw against Kawasaki Frontale after giving up a late spot-kick in the AFC Champions League.
Esteghlal and Zob Ahan were the winnning teams in Monday's AFC Champions League action, the former taking control of Group A.
A whopping 38 goals were scored across eight AFC Champions League ties on a thrilling day of group-stage action.
Esteghlal, Esteghlal Khouzestan and Lokomotiv were the Monday victors in the AFC Champions League group stages.
Al Ahli and Al Rayyan got their AFC Champions League off to a fine start with a win on matchday one.